Obesity, physical activity, and gene-environment interactions: a natural experiment framework.

kg/m 2 in BMI change and 0.335 kg in body weight change during the 2-year follow-up ( P = 0.002 and 0.01), a decrease of approximately 0.23 kg/m 2 in BMI change during the 3-year follow-up ( P = 0.01), and a decrease of approximately 0.23 kg/m 2 in BMI change during the 4-year follow-up, which was at the margin of statistical significance ( P = 0.05).

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And, a cohort study of Singapore, Chinese, and Malaysian populations showed that regular PA attenuated the BMI-increasing effect of the FTO rs9939609 risk allele; however, the interaction between PA and genotype on BMI did not reach statistical significance [ 26 ].

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