Dual PARP/Tankyrase Inhibition Enhances Antitumor Efficacy in PTEN-Deficient Endometrial Cancer.

Consistent with the comet assay findings, PTEN knockdown Hec‐1A cells exhibited an overall trend toward increased DNA damage across treatment conditions, as reflected by elevated γ‐H2AX levels, with statistical significance observed only following olaparib monotherapy (Figure S5B ).

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In the Hec‐1A xenograft model, slight tumour growth inhibition was observed in each treatment group; however, these differences did not reach statistical significance compared to the control group (Figure 1A ).

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