Longitudinal changes in NT-proBNP after breast cancer radiotherapy: clinical determinants of its trajectory and association with cardiac dysfunction (BACCARAT study).

Clin Transl Radiat Oncol · 2026 · PMC13263734 · PMID 42290894

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

marginally significantp = 0.058so close (0.05 < p ≤ 0.1)

A marginally significant interaction of baseline NT-proBNP with time was observed (p = 0.058), with a significant interaction at 24 months post-RT (β = − 0.00051, p = 0.010), indicating a smaller increase, or even a slight decrease, among patients with higher baseline levels in contrast with the increase observed in patients with lower baseline NT-proBNP ( Fig. 1 ).

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did not reach statistical significanceno p-value reported

Although its association with CTRCD did not reach statistical significance, other prospective studies also reported signals of subclinical myocardial injury with higher doses per fraction [25] , [26] .

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