Barely Significant
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CEACAM5 as a biomarker of semi-solid, lepidic lung adenocarcinoma.

Transl Lung Cancer Res · 2026 · PMC13263804 · PMID 42291360

Europe PMCDOI
2
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0.1000
closest p · 2.0× alpha
0.1000
boldest claim

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did not reach statistical significanceP=0.10so close (0.05 < p ≤ 0.1)
Radiographically prior to surgical resection, all lepidic adenocarcinoma GGO specimens with high CEACAM5 expression (n=5) started as radiographic non-solid GGO and then actively developed a new radiographic solid component compared to only 46% of lepidic adenocarcinoma GGO with lower CEACAM5 expression, although this association did not reach statistical significance (100% vs. 46%, P=0.10) ( Table 1 ).

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a possible trendno p-value reported
• Exploratory observation showed high CEACAM5 expression (H-score ≥100) in semi-solid, lepidic lesions may track with radiographic evolution (including emergence of a new radiographic solid component and higher PanCK+ tumor cell composition), suggesting a possible trend with invasiveness in otherwise radiographically indolent-appearing lesions.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.