Age-related differences in GABAergic synapses across the central inferior colliculus in the Fischer Brown Norway rat.

However, there may be significant variations across species as the rat IC appears to have a discontinuous stepwise tonotopic gradient and fewer/no intralaminar compartments at the lower frequencies, thus there may be fewer stellate cells at lower frequencies ( Malmierca et al., 1993 , 1995 , 2005 , 2008 ).

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There was a significant (~29–33 %) downregulation of GABAergic synapses in the high and middle frequency regions of old rats, but a loss (~22 %) in the old low frequency region was not as robust and did not reach statistical significance.

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