Fine-scale structural information substantially improves mRNA therapeutic stability prediction.

Mol Ther Nucleic Acids · 2026 · PMC13264031 · PMID 42293245

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a clear trendno p-value reported

The LO distributions and per-position LO profiles of both VZV and spike sequences showed a clear trend: sequences with more positions at strongly positive LO values tended to have longer half-lives ( Figures 6 B and 6C), consistent with the relationship between local structural confidence and stability observed in the NLuc dataset.

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