Nectin-4 expression in upper and lower tract urothelial carcinoma: correlation with early-stage disease and prognostic relevance.

Virchows Arch · 2026 · PMC13264583 · PMID 40571752

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marginally significantno p-value reported

Cox analysis confirmed that the IS was an independent predictor for PFS and a marginally significant predictor for CSS (Table 3 ).

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did not reach statistical significanceno p-value reported

When subgroup analyses were conducted separately for early- and advanced-stage disease, a trend toward improved prognosis was observed in advanced-stage cases within the Hiroshima cohort; however, some of the results did not reach statistical significance, possibly due to the limited sample size.

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a favorable trendno p-value reported

While not statistical significance, a favorable trend was observed in muscle-invasive UTUC cases (Fig.

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