Efficacy and safety of estrogen therapy for prevention of osteoporosis in postmenopausal women.

Womens Health (Lond) · 2026 · PMC13264665 · PMID 42287137

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did not reach statistical significanceno p-value reported

52 In the WHI trial, there was a 26% increase in invasive breast cancer risk in the CEE/MPA group compared to the placebo group, which did not reach statistical significance (HR=1.26; 95% CI, 1.00-1.59).

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