A pilot cluster randomised controlled trial (n=180) of early cryoprecipitate (two pools) versus placebo in postpartum haemorrhage requiring at least one unit of red blood cells showed a trend to lower requirement for red blood cells, surgical intervention, and admission to the intensive care unit in the cryoprecipitate group. 58 Only 32% of women in the intervention group received the planned cryoprecipitate within 90 min in accordance with the protocol, however, highlighting the fact that giving cryoprecipitate in a timely manner is challenging.
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