Multi-Cohort Transcriptomics Combined with Mendelian Randomization Identifies PPARGC1A, NAAA and GIPC2 as NLRP3 Inflammasome-Related Key Genes in Ulcerative Colitis.

The dynamic tracking diagram of the binding distance between key amino acid residues of PPARGC1A protein and specific small-molecule compounds showed that in both simulations, the binding distance showed a trend of being stable initially and then fluctuating upward, and after the upward trend, the distance fluctuation was roughly maintained within the range of 20–60 nm ( Figure 9E and F ).

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