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Serum progesterone levels for 'rescue' in hormone replacement FET: a retrospective cohort study of 917 cycles.

Front Endocrinol (Lausanne) · 2026 · PMC13265284 · PMID 42305268

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For P4 5–10 ng/mL, the observed outcomes are compatible with proceeding after single-dose IM rescue under this institutional protocol; in the small naturalistic comparison among borderline 9.1–9.9 ng/mL cycles, rescue was associated with a numerically higher LBR (57.1% vs 40.0%) but the 17-percentage-point difference did not reach statistical significance and the comparison is small, non-randomized, and clinician-selected.

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