Association Between Glyco-Lipid Seven-Factor Index, a Novel Composite Glyco-Lipid Index, and Periodontitis: A Cross-Sectional Study.

Int Dent J · 2026 · PMC13265680 · PMID 42247868

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.0580

boldest claim

The sentences

did not reach statistical significanceP = .051so close (0.05 < p ≤ 0.1)

In the fully adjusted Model 3, compared with participants in the lowest quartile (Q1), only those in the third quartile (Q3) exhibited a statistically significant increase in periodontitis risk (OR = 1.36, 95% CI: 1.08-1.71; P = .010), whereas the associations for the second (Q2) and highest quartiles (Q4) did not reach statistical significance (Q2: OR = 1.30, 95% CI: 1.00-1.69; P = .051; Q4: OR = 1.26, 95% CI: 0.98-1.62; P = .068).

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marginally non-significantP = .058so close (0.05 < p ≤ 0.1)

The average causal mediation effect was small and marginally non-significant ( P = .058), with the proportion mediated approaching zero, indicating no substantial indirect effect through hypertension (Supplementary Table 3 and Figure 3 ).This analysis was exploratory and not intended for causal inference.

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