Identification of small ubiquitin-related modifier (SUMO)-related genes-based biomarkers in Alzheimer's disease based on bioinformatics analysis.

Sci Rep · 2026 · PMC13265937 · PMID 42009747

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did not reach statistical significanceno p-value reported

Although PIAS1 did not reach statistical significance in the present clinical sample validation, it consistently showed a significant upregulation trend in two independent datasets, GSE140831 and GSE63060 , and exhibited favorable diagnostic discriminative ability with an AUC exceeding 0.7 in the training set.

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