Lipoprotein(a) and premature myocardial infarction: Mechanistic insights and implications for PCI-era residual risk.

Although pooled risk did not reach statistical significance (RR 1.16, 95% CI 0.93–1.43), the uniform direction of effect across studies, low heterogeneity (I 2 = 24%), and concordance with genetic and mechanistic evidence suggest that Lp(a) contributes meaningfully to residual cardiovascular risk.

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