Circulating erythropoietin concentration associates with thromboembolism in sickle cell disease.

Br J Haematol · 2026 · PMC13266539 · PMID 42052798

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.1800

boldest claim

The sentences

marginal significancep = 0.058so close (0.05 < p ≤ 0.1)

Higher baseline serum EPO concentration associated with increased risk for thromboembolism with a marginal significance (odds ratio [OR] = 1.6, 95% confidence interval [CI] 0.98–2.6, p = 0.058, Table 1 ), adjusting for age, gender, haemoglobin genotype, hydroxyurea therapy, recent blood transfusion and batches of EPO measurement.

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showed a trendp = 0.18not close (p > 0.1)

The G allele of rs322139 showed a trend of association with decreased risk for thromboembolism in UIC (OR = 0.70, p = 0.18, N = 198), adjusting for age, gender, haemoglobin genotypes, hydroxyurea therapy, recent blood transfusion and population stratification.

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highly significantno p-value reported

Adjusting for the same covariates, mediation analysis 32 of the effect of the BCL11A locus on EPO concentration revealed a potential mediation by percent haemoglobin F, with highly significant mediation effect but non-significant direct effect ( Table S6 , Figure 2 ).

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