APOL1 kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

8 The available data regarding other Sub-Saharan African countries are sparse, although the few available studies show a quite significant prevalence of G1/G2 variants across Sub-Saharan Africa. 9 , 29 Based on cohort and cross-sectional studies in the United States, the estimated allelic frequency among African Americans is 20%–22% for G1 and 13%–15% for G2, with approximately 10%–15% having an APOL1 high-risk genotype. 9 The global prevalences of the G1 and G2 alleles and the high-risk genotype are difficult to discern, because these vary widely between regions, many populations are either not tested or have small sampling, and it can be difficult to identify ancestry or ethnicity given gene flow and admixture.

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