Head-to-head comparison of maximum standardized uptake value and three-dimensional consolidation-to-tumor ratio for preoperative prediction of International Association for the Study of Lung Cancer grade 3 in clinical stage IA invasive lung adenocarcinoma.

In multivariable logistic regression analysis, SUVmax remained independently associated with grade 3 [odds ratio (OR) 1.25, 95% confidence interval (CI): 1.13–1.38, P<0.001], whereas 3D-CTR showed only borderline significance (OR 1.01, 95% CI: 1.00–1.02, P=0.050).

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• In multivariable analysis, SUVmax remained independently associated with grade 3, whereas the association of 3D-CTR was weaker and only borderline significant.

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In our additional analyses, serum CEA was significantly higher in pathologically more advanced disease, whereas the difference according to OLNM did not reach statistical significance.

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