Nodal stage is the key prognostic factor in synchronous and metachronous multiple primary colorectal adenocarcinoma after curative-intent resection: a retrospective study.

World J Surg Oncol · 2026 · PMC13267389 · PMID 42050660

Europe PMC DOI

hedged sentences

0.0760

closest p · 1.5× alpha

0.0760

boldest claim

The sentences

did not reach statistical significancep = 0.076so close (0.05 < p ≤ 0.1)

3.81 ± 1.66 cm), but the difference did not reach statistical significance ( p = 0.076).

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a trend toward significanceno p-value reported

095), presence of vascular invasion (HR = 2.519, 95% CI: 1.028–6.172, p = 0.043) and perineural invasion (HR = 1.897, 95% CI: 0.918–3.919, p = 0.084), and positive circumferential resection margin (HR = 6.400, 95% CI: 0.854–47.956, p = 0.071) were associated with worse OS, with several showing only a trend toward significance.

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