CD39 mRNA therapy attenuates localized acute inflammation: A novel anti-inflammatory strategy using cationic nanoliposomes.

Consistent with these observations, histopathological scoring demonstrated none to minimal inflammatory infiltration in the sham (0.14 ± 0.25) and CD39-mRNA-NLp-treated groups (0.13 ± 0.23), with a trend toward increased inflammatory infiltrate in the LPS-only vehicle (1.27 ± 0.64) and empty NLp (1.91 ± 0.85) control groups, although this did not reach statistical significance (P = NS; Figure S9 ).

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