Functional conservation with mechanistic drift: AMP activation in the evolution of archaeal sugar kinases.

In contrast, the α parameter for the PFK reaction demonstrates a clear trend toward a diminished effect on MgADP affinity over evolutionary time ( Fig. 4b , top right panel, red empty circles).

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Variation in both β parameters for GK activity reveals a decreasing trend with evolutionary divergence ( Fig. 4b , bottom left).

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