Impact of hypertension history and blood pressure parameters on cognitive impairment in patients with atrial fibrillation: a systematic review and meta-analysis.

Front Cardiovasc Med · 2026 · PMC13268889 · PMID 42311763

Europe PMC DOI

hedged sentence

0.3500

closest p · 7.0× alpha

0.3500

boldest claim

The sentences

did not reach statistical significanceP = 0.35not close (p > 0.1)

Although the initial analysis of the HR subgroup did not reach statistical significance (HR = 1.04, 95% CI 0.96–1.13, P = 0.35), the increasing risk trend was consistent with the OR subgroup, suggesting the stability of the direction of the association.From a pathophysiological perspective, hypertension and atrial fibrillation (AF) have a synergistic effect on cognitive impairment ( 20 , 29 ).

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