Copper isotope shifts in biofluids track Alzheimer's pathology.

Relationship between serum δ 65 Cu and PET centiloid score For the AD samples from the AIBL cohort (Table S4 ), we observed a negative trend ( p = 0.083) between serum δ 6 5 Cu and amyloid Centiloid burden (Figure 3B ), decreasing proportionally with the accumulation of amyloid plaques. 2 , 27 This serum δ 6 5 Cu may, to some extent, reflect amyloid burden in the brain, albeit less directly and less precisely than PET imaging itself.

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