NADPH oxidase-1 suppression prolongs the antidepressant-like effect of ketamine.

Mol Psychiatry · 2026 · PMC13269138 · PMID 41872515

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did not reach statistical significanceno p-value reported

Western blot analysis confirmed a downward trend in NOX-1 protein levels in both the mPFC (unpaired t-test; p = 0.083) and the LHb (unpaired t-test; p = 0.104) on day 15 in K-4–treated rats, although these differences did not reach statistical significance (Supplemental Figs. 3f , 3g ).

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