Melanoma stem cells drive macrophage reprogramming to a hybrid phenotype, modulating melanoma stemness and compromising NK cell-mediated immunity.

Front Immunol · 2026 · PMC13269258 · PMID 42311672

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did not reach statistical significanceno p-value reported

In contrast, in WM115 SCs, CM from WM115 SC-educated macrophages induced a significant reduction in KLF4 together with increased SOX9 expression, while SOX2 did not reach statistical significance after multiple-testing correction.

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