Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial.

Many observational and interventional studies have investigated the clinical impact of the above prevention measures in patients with an expected mechanical ventilation (MV) duration ≥ 72 h, usually documenting a clear trend toward VAP reduction [ 7 , 8 ].

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