PPP2R3C serves as a negative regulator associated with reduced T cell hyperactivation and renal protection in lupus.

In contrast, the activated CD4 + T cell subset (CD44 + CD62L − CD4 + ) showed a decreasing trend that did not reach statistical significance.

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In the spleen, a modest yet consistent reduction in CD19 + B cells and DN T cells were noted at both time points, alongside a partial restoration of CD3 + , CD4 + and CD8 + T cell populations; however, these changes did not reach statistical significance (Figure S5D ).

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