Pharmacokinetics of Oral Amoxicillin for the Treatment of Syphilis in Pregnancy.

Across the 2 periods, the average C max was 39% lower during pregnancy relative to postpartum, although this did not reach statistical significance (4.2 mg/L vs 6.5 mg/L, respectively; P = .06); the mean CL/F increased by 70% during pregnancy (36.8 L/h vs 21.6 L/h; P = .03), and the mean V/F increased 78% in pregnancy compared with postpartum (73.8 L vs 41.4 L, respectively; P = .03).

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