Genetic analysis of triplicated genes affecting sex-specific skeletal deficits in Down syndrome model mice.

G3 (Bethesda) · 2026 · PMC13270334 · PMID 41788027

Europe PMC DOI

hedged sentence

0.0630

closest p · 1.3× alpha

0.0630

boldest claim

The sentences

approached significanceP = 0.063so close (0.05 < p ≤ 0.1)

The interaction between genotype and mouse model approached significance ( P = 0.063), and contrast analysis within each mouse model indicated trisomic Ts65Dn mice had a significantly lower trabecular composite score than their euploid littermates ( P < 0.001) while trisomic Ts66Yah mice were not significantly different from their euploid littermates ( P = 0.207).

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