Pan-Cancer Analysis of a Depression-Related Gene Signature Identifies an Immunosuppressive Tumor Microenvironment and Links to Immunotherapy Response in Breast Cancer.

Conversely, a positive trend was apparent in the case of deletions, indicating a higher occurrence of deletions among these genes as a collective group in individuals with high DScore ( Figure S2D ).

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Simultaneously, a negative trend in the infiltration of CD8+ T cells was also evident, which supports the description of cold TME ( Figure 5A and C ).

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Therefore, there may be significant differences in protein-level dynamics that need to be considered.

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