This pattern of lower VE estimates with repeated vaccination persisted across all influenza A subtypes ( Figure 2 ), with a particularly pronounced ΔVE of −29.1% (95% CI: −69.9%, 1.8%) observed for A(H3N2), although this estimate did not reach statistical significance.
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Influenza Vaccination Effectiveness Against Influenza-Associated Hospitalization in Children and the Effects of Repeated Vaccination.
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