Barely Significant
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Impact of <i>TP53</i> mutations on survival outcomes in the CAR-T era of large B-cell lymphoma.

Front Immunol · 2026 · PMC13272385 · PMID 42317374

Europe PMCDOI
2
hedged sentences
0.2530
closest p · 5.1× alpha
0.2530
boldest claim

The sentences

did not reach statistical significanceP = 0.253not close (p > 0.1)
9.86 months, P = 0.046; Figure 5D ), although the PFS difference did not reach statistical significance (median PFS: 9.04 vs. 4.01 months, P = 0.253; Figure 5C ).

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highly significantno p-value reported
However, it is noteworthy that the survival advantage of CAR-T therapy remained highly significant (HR = 0.31 for OS) even after rigorous adjustment for these baseline imbalances and TP53 status in our multivariable model.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.