Titin modulation and left ventricular remodelling in chronic primary mitral regurgitation.

Front Cardiovasc Med · 2026 · PMC13272440 · PMID 42318143

Europe PMC DOI

hedged sentences

0.0620

closest p · 1.2× alpha

0.0620

boldest claim

The sentences

a nonsignificant trendp = 0.062so close (0.05 < p ≤ 0.1)

Interestingly, the proportion of the more compliant N2BA isoform was higher in MVP patients with normal LV remodelling (N2BA 36.3%) compared to healthy controls (N2BA 32.4%), and had a nonsignificant trend ( p = 0.062) to be further elevated in patients with disproportionate LV remodelling (N2BA 38.5%), suggesting that N2BA upregulation could be a continuous process in progressive LV dilatation.

also in 5,406 other papers

showed a trendno p-value reported

Disproportionate LV remodelling was correlated with increased phosphorylation and showed a trend towards increased N2BA titin, both markers of decreased myocardial stiffness.

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.