A decoupling strategy toward spatiotemporal regulation and biomechanical transmission of sandwiched scaffold for osteochondral regeneration.

Nat Commun · 2026 · PMC13272660 · PMID 41997947

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an increasing trendno p-value reported

It could be seen that at both time points, the expression levels of COL2A1 in the blank group, NCCL-CG group, FCCL-DG group, and WCCL-DG group showed an increasing trend, and the WCCL-DG group was closest to the Sham group (Fig. 8a,b ).

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a clear trendno p-value reported

Through Micro-CT analysis, newborn bone tissues in the hydrogel groups were arranged in an orderly manner, showing a clear trend of growth along the scaffold direction, while the appeared bone tissues of the blank group were disorderedly distributed and granular.

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