Loss of erythrocyte sialic acid in sepsis disrupts inhibitory Siglec interactions, driving neutrophil hyperactivation and NET outspread.

Proc Natl Acad Sci U S A · 2026 · PMC13273359 · PMID 42268890

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did not reach statistical significanceno p-value reported

Nevertheless, RBCs from intact mice showed a similar tendency to inhibit NET formation, although the effect did not reach statistical significance ( SI Appendix , Fig.

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