Causal Effects and Single-Cell Microenvironmental Implications of Germline Variant-Regulated Lactylation-Related Pro-Oncogenic Genes in Colorectal Cancer.

Hum Mutat · 2026 · PMC13273392 · PMID 42317214

Europe PMC DOI

hedged sentences

0.1101

closest p · 2.2× alpha

0.1101

boldest claim

The sentences

an increasing trendp = 0.1101not close (p > 0.1)

Although AXIN1 showed an increasing trend in stromal cells, this difference did not reach statistical significance ( p = 0.1101), and no significant differences were observed in T cells or B cells (Figure 3 F).

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did not reach statistical significanceno p-value reported

Although the GWAS Egger analysis did not reach statistical significance, the effect direction remained positive, indicating good consistency of the AXIN1 GWAS results across different methods (Figure 1 ).

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