Taming the "death receptor": translating the first-in-class p75<sup>NTR</sup> modulator LM11A-31 from basic biology, across broad preclinical models, to clinical proof-of-concept.

J Transl Med · 2026 · PMC13274216 · PMID 42210251

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did not reach statistical significanceno p-value reported

Total tau and p-tau181 levels were reduced but did not reach statistical significance.

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Taming the "death receptor": translating the first-in-class p75&lt;sup&gt;NTR&lt;/sup&gt; modulator LM11A-31 from basic biology, across broad preclinical models, to clinical proof-of-concept.

The sentences

Taming the "death receptor": translating the first-in-class p75<sup>NTR</sup> modulator LM11A-31 from basic biology, across broad preclinical models, to clinical proof-of-concept.