Loss of the actin remodeling protein Flightless-1 impairs CD8 and regulatory T cell function.

In the spleens and lungs of infected animals, the frequency and number of FLII-deficient OT-1 cells were significantly lower than WT OT-1 cells at nearly all timepoints examined, whereas in the medLN the trend was similar but did not reach statistical significance other than at 7 dpi ( Fig. 3C ).

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