Potential antidepressant properties of aminophylline in male mice exposed to chronic restraint stress.

Mean immobility times for aminophylline (10 mg/kg: 78.8 s; 20 mg/kg: 58.4 s) were lower than those observed with fluoxetine (95.2 s), although the differences did not reach statistical significance.

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This is highly significant given that there is now increasing evidence linking neuroinflammation and immune dysfunction to the pathophysiology of depression and the development of treatment resistance [ 10 , 11 ].

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