Loss of Hfe impairs hematopoietic stem and progenitor cell function.

We found a significant reduction in the number of LKS HSPCs, including multipotent progenitor populations (MPPs) and nearly significant loss of long-term (LT)-HSCs in Hfe -KO mice compared with WT animals ( Figure 1 C), a phenotype not observed in mice lacking Hamp1 ( Figure 1 D).

also in 3,287 other papers