SM03, a non-depleting anti-CD22 antibody, modulates B cell activation and immune crosstalk to attenuate autoimmunity.

J Transl Autoimmun · 2026 · PMC13276457 · PMID 42327873

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showed a trendno p-value reported

However, HD significantly modulated circulating plasmablasts and CD4 + T helper cells, while SM03 treatment showed a trend toward reducing class-switched B cells, T cells and macrophages ( Fig. 5 C and D).

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