Effects of SGLT2 inhibition on incident heart failure in carriers of cardiomyopathy-associated genetic variants.

Nat Med · 2026 · PMC13278951 · PMID 42260102

Europe PMC DOI

hedged sentence

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

did not reach statistical significanceP = 0.08so close (0.05 < p ≤ 0.1)

While carriers of CMP-associated variants with a history of HF had a numerically higher risk compared with noncarriers, this did not reach statistical significance (HR 2.98, 95% CI 0.88–10.20; P = 0.08).

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