Targeted therapies plus radiotherapy for diffuse intrinsic pontine glioma: the randomized phase 2 BIOMEDE trial.

Nat Med · 2026 · PMC13279265 · PMID 42032072

Europe PMC DOI

hedged sentences

0.0640

closest p · 1.3× alpha

0.1085

boldest claim

The sentences

borderline significantP = 0.064so close (0.05 < p ≤ 0.1)

We observed a borderline significant association between histone mutation and OS in univariate analysis ( P = 0.064); compared to H3 wild-type (H3-WT), the outcome was worse in patients with H3.3K27M (hazard ratio = 1.28 (95% CI: 0.81−2.03)) and better in patients with H3.1K27M (hazard ratio = 0.81 (95% CI: 0.46−1.42)).

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showed a trendP = 0.1085not close (p > 0.1)

Overexpression of the PI3K/AKT/MTOR signature showed a trend toward improved response to everolimus (interaction P = 0.1085).

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.