Cardiovascular Health Characterization Using Life's Essential 8 Score in Perimenopausal Women: An Analysis of the National Health and Nutritional Examination Survey.

In the premenopausal stage, the LE8 component scores showed an increasing trend through the survey cycles of the study period from 2007 to 2008 through 2017 to 2020 for blood lipids (72.4±1.2 to 81.1±1.0; P trend <0.001], sleep (82.5±1.2 to 86.2±0.8; P trend <0.001), and smoking (71.3±2.2 to 79.1±1.6; P trend 0.04].

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Similarly, the scores showed a decreasing trend for blood sugar (92.8±0.5 to 89.9±0.8; P trend <0.001), BMI (66.0±1.8 to 59.3±1.9; P trend <0.001), and diet (45.5±1.3 to 39.7±1.3; P trend <0.0001) through the same study period.

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The age‐adjusted odds for a poor overall LE8 score among postmenopausal women with premenopausal women as reference were 29% higher but did not reach statistical significance (OR adj , 1.29 [95% CI, 0.96–1.73]).

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