Association of Polygenic Risk Scores With Aortic Valve Calcium: The Multi-Ethnic Study of Atherosclerosis.

J Am Heart Assoc · 2026 · PMC13279466 · PMID 42089167

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borderline significantno p-value reported

In sex‐stratified analyses, the PRS for coronary artery disease, low‐density lipoprotein cholesterol, and lipoprotein(a) were significantly associated with AVC >0 for both sexes ( P <0.05), whereas the systolic blood pressure PRS was borderline significant for women (HR, 1.10 [95% CI, 0.97–1.25]) and significant for men (HR, 1.11 [95% CI 1.00–1.24]).

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nominally significantno p-value reported

The PRS for triglycerides had a nominally significant association that was not significant after Bonferroni correction.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.