Dietary Spermidine Mitigates Radiation-Induced Intestinal Injury by Reshaping the Microbiota-Barrier-Inflammation Axis.

Food Sci Nutr · 2026 · PMC13279875 · PMID 42326436

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Notably, the low dose of 5 mg/kg in mice gives an HED of approximately 0.4 mg/kg/day (24 mg/day for a 60 kg adult), which also showed a trend of alleviating intestinal injury and significantly prolonged the median survival time of irradiated mice.

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