Impact of the COVID-19 Pandemic on Outpatient Visit-Based Frequency Trends of Herpes Zoster Ophthalmicus.

In the absolute-count Poisson model without the outpatient-visit denominator, the HZO slope-change estimate remained positive but was not conventionally significant (IRR=1.074, 95% CI 0.991 to 1.165; p=0.081), suggesting that pandemic-related changes in outpatient utilization may have contributed to the magnitude of the proportion-based effect.

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The proportion of patients with any ocular complication was higher in the post-pandemic period, but this difference did not reach statistical significance.

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While the time series analysis indicated no immediate surge in the relative frequency of HZO at the pandemic's start, it revealed a highly significant acceleration in the long-term increasing trend of HZO cases.

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