Inhibition of FAAH suppresses RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss partially through repressing the IL17 pathway.

Notably, intervening RANKL‐induced BMMs with IL17 alone showed a trend of promoting osteoclast differentiation, but the difference is not statistically significant, which was similar to a previous study, which showed that IL17 had no significant effect on osteoclast formation induced by RANKL, but promoted osteoclastogenesis in a co‐culture system, suggesting that IL17 did not act directly on osteoclast precursor cells. 82 In addition, previous studies have shown that IL17 is closely related to OVX‐mediated bone loss.

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