R-α-Lipoic Acid Attenuates Acetaminophen-Induced Acute Liver Injury by Reducing Oxidative Stress, Inflammation, and Mitochondrial Damage in Mice.

Although the repeated R-ALA pretreatment showed numerically greater improvements than the single-dose pretreatment in several markers—including ALT, AST, GLDH, K18, ccK18, IL-6, TNF-α, MDA, GSH, SOD, and GPx3—these differences did not reach statistical significance.

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