cGAMP-Loaded M2e Nanovaccine Elicits Cross-Reactive Immunity and Mitigates H6N1 Avian Influenza Infection in Chickens.

Compared with the unvaccinated and ISA-adjuvanted groups, a trend toward reduced viral RNA levels was detected in chickens immunized with the M2e nanoshell vaccine, although the difference did not reach statistical significance ( Figure 5F ).

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