Contextual variability in under-diagnosed cardiometabolic disease and cognitive vulnerability among populations at high risk for Alzheimer's disease and related dementias.

NPJ Dement · 2026 · PMC13282169 · PMID 42327424

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

showed a trendp = 0.06so close (0.05 < p ≤ 0.1)

Overt diabetes defined by FBG ≥ 126 mg/dL was associated with higher NfL (β = 0.37, SE = 0.09, p < 0.001) and showed a trend towards an inverse association with the Aβ42/40 (β = -0.27, SE = 0.14, p = 0.06).

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marginal significanceno p-value reported

Associations with p‐values between 0.05 and 0.10 were considered exploratory trends, with interpretation emphasizing consistency and substantive relevance rather than marginal significance.

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